PREMARIN vs VIVELLE-DOT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. PREMARIN and VIVELLE-DOT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PREMARIN	VIVELLE-DOT
Rating	New	68/100
Pharmacy pays	—	$6.55 /g
Type	RX	RX
Active ingredient	ESTROGENS, CONJUGATED	ESTRADIOL
Manufacturer	Wyeth Pharms Inc	Sandoz
Dosage forms	Tablet	Patch, extended release
Drug class	Estrogen	Estrogen
Boxed warning	Boxed warning	Boxed warning
Treats	—	Breast Neoplasms, Hypogonadism, Premature Menopause

premarin vivelle-dot

Rating

New

68/100

Pharmacy pays

—

$6.55 /g

Type

Active ingredient

ESTROGENS, CONJUGATED

ESTRADIOL

Manufacturer

Wyeth Pharms Inc

Sandoz

Dosage forms

Tablet

Patch, extended release

Drug class

Estrogen

Boxed warning

Treats

—

Breast Neoplasms, Hypogonadism, Premature Menopause

Frequently asked questions

What is the difference between Premarin and Vivelle-Dot?

Premarin contains Estrogens, Conjugated, while Vivelle-Dot contains Estradiol — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.