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PRED-G vs RETIN-A

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. PRED-G and RETIN-A are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
74/100

Pharmacy pays

$0.97 /g
$1.05 /g

Type

RX
RX

Active ingredient

GENTAMICIN SULFATE AND PREDNISOLONE ACETATE
TRETINOIN

Dosage forms

Drops, Topical
Topical

Drug class

—
Retinoid

Boxed warning

None
None

Half-life

2 to 4 hours
—

Treats

—
Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

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Frequently asked questions

Which is better-rated, Pred-G or Retin-A?

By our independent rating, Retin-A scores higher — 3.7 vs 3.6 out of 5 for Pred-G. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Pred-G or Retin-A?

Pred-G costs pharmacies less to acquire — about $0.97 vs $1.05 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Pred-G and Retin-A?

Pred-G contains Gentamicin Sulfate and Prednisolone Acetate, while Retin-A contains Tretinoin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.