PRECEDEX vs ZANAFLEX

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. PRECEDEX and ZANAFLEX are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PRECEDEX	ZANAFLEX
Rating	60/100	New
Pharmacy pays	—	~$1.00 /30
Type	RX	RX
Active ingredient	DEXMEDETOMIDINE HYDROCHLORIDE	TIZANIDINE HYDROCHLORIDE
Manufacturer	Hospira	Legacy Pharma
Dosage forms	Injectable	Capsule, Tablet
Drug class	Central Alpha-2 Adrenergic Agonist	Central Alpha-2 Adrenergic Agonist
Boxed warning	None	None
Half-life	—	about 2.5 hours
Treats	Pain, Psychomotor Agitation	Muscle Cramp, Muscle Rigidity, Muscle Spasticity

precedex zanaflex

Rating

60/100

New

Pharmacy pays

—

~$1.00 /30

Type

Active ingredient

DEXMEDETOMIDINE HYDROCHLORIDE

TIZANIDINE HYDROCHLORIDE

Manufacturer

Hospira

Legacy Pharma

Dosage forms

Injectable

Capsule, Tablet

Drug class

Central Alpha-2 Adrenergic Agonist

Boxed warning

None

Half-life

—

about 2.5 hours

Treats

Pain, Psychomotor Agitation

Muscle Cramp, Muscle Rigidity, Muscle Spasticity

Frequently asked questions

What is the difference between Precedex and Zanaflex?

Precedex contains Dexmedetomidine Hydrochloride, while Zanaflex contains Tizanidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.