POSFREA vs ZOFRAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. POSFREA and ZOFRAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	POSFREA	ZOFRAN
Rating	New	68/100
Pharmacy pays	—	$0.15 /mL
Type	RX	RX
Active ingredient	PALONOSETRON HYDROCHLORIDE	ONDANSETRON HYDROCHLORIDE
Manufacturer	Avyxa Holdings	Sandoz
Dosage forms	Injectable	Tablet
Drug class	Serotonin-3 Receptor Antagonist	Serotonin-3 Receptor Antagonist
Boxed warning	None	None
Half-life	—	about 3 to 5 hours (roughly 4 hours) in healthy adults
Treats	—	Alcoholism

posfrea zofran

Rating

New

68/100

Pharmacy pays

—

$0.15 /mL

Type

Active ingredient

PALONOSETRON HYDROCHLORIDE

ONDANSETRON HYDROCHLORIDE

Manufacturer

Avyxa Holdings

Sandoz

Dosage forms

Injectable

Tablet

Drug class

Serotonin-3 Receptor Antagonist

Boxed warning

None

Half-life

—

about 3 to 5 hours (roughly 4 hours) in healthy adults

Treats

—

Alcoholism

Frequently asked questions

What is the difference between Posfrea and Zofran?

Posfrea contains Palonosetron Hydrochloride, while Zofran contains Ondansetron Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.