PLIAGLIS vs SYNERA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Attribute	PLIAGLIS	SYNERA
Rating	New	New
Pharmacy pays	$0.29 /mL	$0.29 /mL
Type	RX	RX
Active ingredient	LIDOCAINE AND TETRACAINE	LIDOCAINE AND TETRACAINE
Manufacturer	Crescita Therap	Galen Specialty
Dosage forms	Topical	Patch
Drug class	—	—
Boxed warning	None	None

pliaglis synera

Rating

New

Pharmacy pays

$0.29 /mL

Type

Active ingredient

LIDOCAINE AND TETRACAINE

Manufacturer

Crescita Therap

Galen Specialty

Dosage forms

Topical

Patch

Drug class

—

Boxed warning

None

Frequently asked questions

Which is cheaper, Pliaglis or Synera?

Pharmacies pay about the same to acquire either one — roughly $0.29 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Pliaglis and Synera?

Both Pliaglis and Synera share the active ingredient Lidocaine and Tetracaine.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.