PLEGINE vs WEGOVY

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. PLEGINE and WEGOVY are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PLEGINE	WEGOVY
Rating	New	70/100
Pharmacy pays	~$3.86 /30	—
Type	RX	RX
Active ingredient	PHENDIMETRAZINE TARTRATE	SEMAGLUTIDE
Manufacturer	Wyeth Ayerst	Novo Nordisk
Dosage forms	Tablet	Injectable, Tablet
Drug class	Sympathomimetic Amine Anorectic	Glp-1 Receptor Agonist
Boxed warning	None	Boxed warning
Half-life	—	about 1 week (roughly 7 days)
Treats	Obesity	Obesity, Overweight

plegine wegovy

Rating

New

70/100

Pharmacy pays

~$3.86 /30

—

Type

Active ingredient

PHENDIMETRAZINE TARTRATE

SEMAGLUTIDE

Manufacturer

Wyeth Ayerst

Novo Nordisk

Dosage forms

Tablet

Injectable, Tablet

Drug class

Sympathomimetic Amine Anorectic

Glp-1 Receptor Agonist

Boxed warning

None

Boxed warning

Half-life

—

about 1 week (roughly 7 days)

Treats

Obesity

Obesity, Overweight

Frequently asked questions

What is the difference between Plegine and Wegovy?

Plegine contains Phendimetrazine Tartrate, while Wegovy contains Semaglutide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.