PLEGINE vs TEPANIL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. PLEGINE and TEPANIL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PLEGINE	TEPANIL
Rating	New	New
Pharmacy pays	~$3.86 /30	~$7.96 /30
Type	RX	RX
Active ingredient	PHENDIMETRAZINE TARTRATE	DIETHYLPROPION HYDROCHLORIDE
Manufacturer	Wyeth Ayerst	3m
Dosage forms	Tablet	Tablet
Drug class	Sympathomimetic Amine Anorectic	Sympathomimetic Amine Anorectic
Boxed warning	None	None
Treats	Obesity	Obesity

plegine tepanil

Rating

New

Pharmacy pays

~$3.86 /30

~$7.96 /30

Type

Active ingredient

PHENDIMETRAZINE TARTRATE

DIETHYLPROPION HYDROCHLORIDE

Manufacturer

Wyeth Ayerst

Dosage forms

Tablet

Drug class

Sympathomimetic Amine Anorectic

Boxed warning

None

Treats

Obesity

Frequently asked questions

Which is cheaper, Plegine or Tepanil?

Plegine costs pharmacies less to acquire — about $3.86 vs $7.96 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Plegine and Tepanil?

Plegine contains Phendimetrazine Tartrate, while Tepanil contains Diethylpropion Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.