PLEGINE vs TENUATE DOSPAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 11, 2026·How we rate

Possible drug interaction. PLEGINE and TENUATE DOSPAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PLEGINE	TENUATE DOSPAN
Rating	New	70/100
Pharmacy pays	~$3.86 /30	~$7.96 /30
Type	RX	RX
Active ingredient	PHENDIMETRAZINE TARTRATE	DIETHYLPROPION HYDROCHLORIDE
Manufacturer	Wyeth Ayerst	Ani Pharms
Dosage forms	Tablet	Tablet, extended release
Drug class	Sympathomimetic Amine Anorectic	Sympathomimetic Amine Anorectic
Boxed warning	None	None
Treats	Obesity	Obesity

plegine tenuate dospan

Rating

New

70/100

Pharmacy pays

~$3.86 /30

~$7.96 /30

Type

Active ingredient

PHENDIMETRAZINE TARTRATE

DIETHYLPROPION HYDROCHLORIDE

Manufacturer

Wyeth Ayerst

Ani Pharms

Dosage forms

Tablet

Tablet, extended release

Drug class

Sympathomimetic Amine Anorectic

Boxed warning

None

Treats

Obesity

Frequently asked questions

Which is cheaper, Plegine or Tenuate Dospan?

Plegine costs pharmacies less to acquire — about $3.86 vs $7.96 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Plegine and Tenuate Dospan?

Plegine contains Phendimetrazine Tartrate, while Tenuate Dospan contains Diethylpropion Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.