PLEGINE vs SUPRENZA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. PLEGINE and SUPRENZA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PLEGINE	SUPRENZA
Rating	New	New
Pharmacy pays	~$3.86 /30	~$2.54 /30
Type	RX	RX
Active ingredient	PHENDIMETRAZINE TARTRATE	PHENTERMINE HYDROCHLORIDE
Manufacturer	Wyeth Ayerst	Citius Pharms
Dosage forms	Tablet	Tablet, orally disintegrating
Drug class	Sympathomimetic Amine Anorectic	Sympathomimetic Amine Anorectic
Boxed warning	None	None
Treats	Obesity	Obesity

plegine suprenza

Rating

New

Pharmacy pays

~$3.86 /30

~$2.54 /30

Type

Active ingredient

PHENDIMETRAZINE TARTRATE

PHENTERMINE HYDROCHLORIDE

Manufacturer

Wyeth Ayerst

Citius Pharms

Dosage forms

Tablet

Tablet, orally disintegrating

Drug class

Sympathomimetic Amine Anorectic

Boxed warning

None

Treats

Obesity

Frequently asked questions

Which is cheaper, Plegine or Suprenza?

Suprenza costs pharmacies less to acquire — about $2.54 vs $3.86 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Plegine and Suprenza?

Plegine contains Phendimetrazine Tartrate, while Suprenza contains Phentermine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.