PLAN B ONE-STEP vs SKYLA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Attribute	PLAN B ONE-STEP	SKYLA
Rating	New	New
Pharmacy pays	~$192.31 /30	~$192.31 /30
Type	OTC	RX
Active ingredient	LEVONORGESTREL	LEVONORGESTREL
Manufacturer	Fdn Consumer	Bayer Hlthcare
Dosage forms	Tablet	IUD
Drug class	Progestin	Progestin
Boxed warning	None	None
Half-life	about 36 hours (36 ± 13 hours at steady state)	about 36 hours (36 ± 13 hours at steady state)

plan b one-step skyla

Rating

New

Pharmacy pays

~$192.31 /30

Type

OTC

Active ingredient

LEVONORGESTREL

Manufacturer

Fdn Consumer

Bayer Hlthcare

Dosage forms

Tablet

IUD

Drug class

Progestin

Boxed warning

None

Half-life

about 36 hours (36 ± 13 hours at steady state)

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Where to buy

Buy over-the-counter from trusted retailers.

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Frequently asked questions

Which is cheaper, Plan B One-Step or Skyla?

Pharmacies pay about the same to acquire either one — roughly $192.31 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Plan B One-Step and Skyla?

Both Plan B One-Step and Skyla share the active ingredient Levonorgestrel, but Plan B One-Step is sold as OTC and Skyla as RX.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.