Skip to content
ppharmaranks
Menu

PHENERGAN vs PROCHLORPERAZINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. PHENERGAN and PROCHLORPERAZINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
70/100

Pharmacy pays

~$1.53 /30
~$5.22 /30

Type

RX
RX

Active ingredient

PROMETHAZINE HYDROCHLORIDE
PROCHLORPERAZINE MALEATE

Dosage forms

Injectable
Suppository, Tablet

Drug class

Phenothiazine
Phenothiazine

Boxed warning

Half-life

about 9 to 16 hours

Treats

Anaphylaxis, Allergic Conjunctivitis, Motion Sickness
Anxiety Disorders, Dementia, Nausea

Frequently asked questions

Which is cheaper, Phenergan or Prochlorperazine?

Phenergan costs pharmacies less to acquire — about $1.53 vs $5.22 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Phenergan and Prochlorperazine?

Phenergan contains Promethazine Hydrochloride, while Prochlorperazine contains Prochlorperazine Maleate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.