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PERPHENAZINE vs PROCHLORPERAZINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. PERPHENAZINE and PROCHLORPERAZINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

68/100
70/100

Pharmacy pays

~$5.68 /30
~$5.22 /30

Type

RX
RX

Active ingredient

PERPHENAZINE
PROCHLORPERAZINE MALEATE

Manufacturer

Dosage forms

Tablet
Suppository, Tablet

Drug class

Phenothiazine
Phenothiazine

Boxed warning

Treats

Tourette Syndrome, Huntington Disease, Nausea
Anxiety Disorders, Dementia, Nausea

Frequently asked questions

Which is better-rated, Perphenazine or Prochlorperazine?

By our independent rating, Prochlorperazine scores higher — 3.5 vs 3.4 out of 5 for Perphenazine. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Perphenazine or Prochlorperazine?

Prochlorperazine costs pharmacies less to acquire — about $5.22 vs $5.68 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Perphenazine and Prochlorperazine?

Perphenazine contains Perphenazine, while Prochlorperazine contains Prochlorperazine Maleate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.