PEPCID vs PEPCID AC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	PEPCID	PEPCID AC
Rating	New	70/100
Pharmacy pays	~$1.54 /30	~$1.54 /30
Type	RX	OTC
Active ingredient	FAMOTIDINE	FAMOTIDINE
Manufacturer	Bausch	Kenvue Brands
Dosage forms	Tablet	Tablet
Drug class	Histamine-2 Receptor Antagonist	Histamine-2 Receptor Antagonist
Boxed warning	None	None
Half-life	2.5 to 3.5 hours	2.5 to 3.5 hours
Treats	Duodenal Ulcer, Dyspepsia, Peptic Esophagitis	Duodenal Ulcer, Dyspepsia, Peptic Esophagitis

pepcid pepcid ac

Rating

New

70/100

Pharmacy pays

~$1.54 /30

Type

OTC

Active ingredient

FAMOTIDINE

Manufacturer

Bausch

Kenvue Brands

Dosage forms

Tablet

Drug class

Histamine-2 Receptor Antagonist

Boxed warning

None

Half-life

2.5 to 3.5 hours

Treats

Duodenal Ulcer, Dyspepsia, Peptic Esophagitis

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Frequently asked questions

Which is cheaper, Pepcid or Pepcid Ac?

Pharmacies pay about the same to acquire either one — roughly $1.54 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Pepcid and Pepcid Ac?

Both Pepcid and Pepcid Ac share the active ingredient Famotidine, but Pepcid is sold as RX and Pepcid Ac as OTC.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.