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PEPCID RPD vs TAGAMET

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. PEPCID RPD and TAGAMET are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

pepcid rpdtagamet

Rating

70/100
70/100

Pharmacy pays

~$1.54 /30
~$9.92 /30

Type

RX
RX

Active ingredient

FAMOTIDINE
CIMETIDINE HYDROCHLORIDE

Manufacturer

Merck
Glaxosmithkline

Dosage forms

Tablet, orally disintegrating
Tablet

Drug class

Histamine-2 Receptor Antagonist
Histamine-2 Receptor Antagonist

Boxed warning

None
None

Half-life

2.5 to 3.5 hours
—

Treats

Duodenal Ulcer, Dyspepsia, Peptic Esophagitis
Duodenal Ulcer, Dyspepsia, Peptic Esophagitis

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Frequently asked questions

Which is better-rated, Pepcid Rpd or Tagamet?

Pepcid Rpd and Tagamet are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Pepcid Rpd or Tagamet?

Pepcid Rpd costs pharmacies less to acquire — about $1.54 vs $9.92 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Pepcid Rpd and Tagamet?

Pepcid Rpd contains Famotidine, while Tagamet contains Cimetidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.