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PEPCID PRESERVATIVE FREE vs TAGAMET HB

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Rating

70/100
70/100

Pharmacy pays

~$1.54 /30
~$9.92 /30

Type

RX
OTC

Active ingredient

FAMOTIDINE
CIMETIDINE

Dosage forms

Injectable
Tablet

Drug class

Histamine-2 Receptor Antagonist
Histamine-2 Receptor Antagonist

Boxed warning

None
None

Half-life

2.5 to 3.5 hours

Treats

Duodenal Ulcer, Dyspepsia, Peptic Esophagitis
Duodenal Ulcer, Dyspepsia, Peptic Esophagitis

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

Which is better-rated, Pepcid Preservative Free or Tagamet Hb?

Pepcid Preservative Free and Tagamet Hb are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Pepcid Preservative Free or Tagamet Hb?

Pepcid Preservative Free costs pharmacies less to acquire — about $1.54 vs $9.92 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Pepcid Preservative Free and Tagamet Hb?

Pepcid Preservative Free contains Famotidine, while Tagamet Hb contains Cimetidine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.