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PEPCID AC vs TAGAMET

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Rating

70/100
72/100

Pharmacy pays

~$1.54 /30
~$9.58 /30

Type

OTC
RX

Active ingredient

FAMOTIDINE
CIMETIDINE HYDROCHLORIDE

Dosage forms

Tablet
Tablet

Drug class

Histamine-2 Receptor Antagonist
Histamine-2 Receptor Antagonist

Boxed warning

None
None

Half-life

2.5 to 3.5 hours
—

Treats

Duodenal Ulcer, Dyspepsia, Peptic Esophagitis
Duodenal Ulcer, Dyspepsia, Peptic Esophagitis

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Frequently asked questions

Which is better-rated, Pepcid Ac or Tagamet?

By our independent rating, Tagamet scores higher — 3.6 vs 3.5 out of 5 for Pepcid Ac. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Pepcid Ac or Tagamet?

Pepcid Ac costs pharmacies less to acquire — about $1.54 vs $9.58 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Pepcid Ac and Tagamet?

Pepcid Ac contains Famotidine, while Tagamet contains Cimetidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.