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PEPCID AC vs RANITIDINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate
pepcid acranitidine hydrochloride

Rating

70/100
70/100

Pharmacy pays

~$1.54 /30
—

Type

OTC
RX

Active ingredient

FAMOTIDINE
RANITIDINE HYDROCHLORIDE

Manufacturer

Kenvue Brands
Wockhardt

Dosage forms

Tablet
Capsule

Drug class

Histamine-2 Receptor Antagonist
—

Boxed warning

None
None

Half-life

2.5 to 3.5 hours
about 2.5 to 3 hours

Treats

Duodenal Ulcer, Dyspepsia, Peptic Esophagitis
Duodenal Ulcer, Peptic Esophagitis, Gastroesophageal Reflux

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Where to buy

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Frequently asked questions

Which is better-rated, Pepcid Ac or Ranitidine Hydrochloride?

Pepcid Ac and Ranitidine Hydrochloride are tied at 3.5 out of 5 by our independent rating.

What is the difference between Pepcid Ac and Ranitidine Hydrochloride?

Pepcid Ac contains Famotidine, while Ranitidine Hydrochloride contains Ranitidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.