PEPCID AC vs PEPCID RPD

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Attribute	PEPCID AC	PEPCID RPD
Rating	70/100	72/100
Pharmacy pays	~$1.54 /30	~$1.54 /30
Type	OTC	RX
Active ingredient	FAMOTIDINE	FAMOTIDINE
Manufacturer	Kenvue Brands	Merck
Dosage forms	Tablet	Tablet, orally disintegrating
Drug class	Histamine-2 Receptor Antagonist	Histamine-2 Receptor Antagonist
Boxed warning	None	None
Half-life	2.5 to 3.5 hours	2.5 to 3.5 hours
Treats	Duodenal Ulcer, Dyspepsia, Peptic Esophagitis	Duodenal Ulcer, Dyspepsia, Peptic Esophagitis

pepcid ac pepcid rpd

Rating

70/100

72/100

Pharmacy pays

~$1.54 /30

Type

OTC

Active ingredient

FAMOTIDINE

Manufacturer

Kenvue Brands

Merck

Dosage forms

Tablet

Tablet, orally disintegrating

Drug class

Histamine-2 Receptor Antagonist

Boxed warning

None

Half-life

2.5 to 3.5 hours

Treats

Duodenal Ulcer, Dyspepsia, Peptic Esophagitis

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Frequently asked questions

Which is better-rated, Pepcid Ac or Pepcid Rpd?

By our independent rating, Pepcid Rpd scores higher — 3.6 vs 3.5 out of 5 for Pepcid Ac. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Pepcid Ac or Pepcid Rpd?

Pharmacies pay about the same to acquire either one — roughly $1.54 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Pepcid Ac and Pepcid Rpd?

Both Pepcid Ac and Pepcid Rpd share the active ingredient Famotidine, but Pepcid Ac is sold as OTC and Pepcid Rpd as RX.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.