PEPCID AC vs PEPCID PRESERVATIVE FREE IN PLASTIC CONTAINER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Attribute	PEPCID AC	PEPCID PRESERVATIVE FREE IN PLASTIC CONTAINER
Rating	70/100	72/100
Pharmacy pays	~$1.54 /30	~$1.54 /30
Type	OTC	RX
Active ingredient	FAMOTIDINE	FAMOTIDINE
Manufacturer	Kenvue Brands	Merck Sharp Dohme
Dosage forms	Tablet	Injectable
Drug class	Histamine-2 Receptor Antagonist	Histamine-2 Receptor Antagonist
Boxed warning	None	None
Half-life	2.5 to 3.5 hours	2.5 to 3.5 hours
Treats	Duodenal Ulcer, Dyspepsia, Peptic Esophagitis	Duodenal Ulcer, Dyspepsia, Peptic Esophagitis

pepcid ac pepcid preservative free in plastic container

Rating

70/100

72/100

Pharmacy pays

~$1.54 /30

Type

OTC

Active ingredient

FAMOTIDINE

Manufacturer

Kenvue Brands

Merck Sharp Dohme

Dosage forms

Tablet

Injectable

Drug class

Histamine-2 Receptor Antagonist

Boxed warning

None

Half-life

2.5 to 3.5 hours

Treats

Duodenal Ulcer, Dyspepsia, Peptic Esophagitis

Get pepcid ac

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Get treatment online

Licensed online providers — consult & get prescribed if eligible.

SesameCompare online visit prices

Where to buy

Buy over-the-counter from trusted retailers.

AmazonCheck price on Amazon

Frequently asked questions

Which is better-rated, Pepcid Ac or Pepcid Preservative Free in Plastic Container?

By our independent rating, Pepcid Preservative Free in Plastic Container scores higher — 3.6 vs 3.5 out of 5 for Pepcid Ac. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Pepcid Ac or Pepcid Preservative Free in Plastic Container?

Pharmacies pay about the same to acquire either one — roughly $1.54 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Pepcid Ac and Pepcid Preservative Free in Plastic Container?

Both Pepcid Ac and Pepcid Preservative Free in Plastic Container share the active ingredient Famotidine, but Pepcid Ac is sold as OTC and Pepcid Preservative Free in Plastic Container as RX.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.