PENNSAID vs PIROXICAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. PENNSAID and PIROXICAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PENNSAID	PIROXICAM
Rating	New	72/100
Pharmacy pays	$0.36 /mL	~$5.35 /30
Type	RX	RX
Active ingredient	DICLOFENAC SODIUM	PIROXICAM
Manufacturer	Horizon	Unichem
Dosage forms	Solution	Capsule
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	Boxed warning
Half-life	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)	—
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea	Rheumatoid Arthritis, Inflammation, Osteoarthritis

pennsaid piroxicam

Rating

New

72/100

Pharmacy pays

$0.36 /mL

~$5.35 /30

Type

Active ingredient

DICLOFENAC SODIUM

PIROXICAM

Manufacturer

Horizon

Unichem

Dosage forms

Solution

Capsule

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Boxed warning

Half-life

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

—

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Rheumatoid Arthritis, Inflammation, Osteoarthritis

Frequently asked questions

What is the difference between Pennsaid and Piroxicam?

Pennsaid contains Diclofenac Sodium, while Piroxicam contains Piroxicam — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.