PAMELOR vs TOFRANIL-PM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. PAMELOR and TOFRANIL-PM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PAMELOR	TOFRANIL-PM
Rating	70/100	70/100
Pharmacy pays	$0.17 /mL	~$100.18 /30
Type	RX	RX
Active ingredient	NORTRIPTYLINE HYDROCHLORIDE	IMIPRAMINE PAMOATE
Manufacturer	Specgx LLC	Specgx LLC
Dosage forms	Capsule	Capsule
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	None	None
Treats	Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

pamelor tofranil-pm

Rating

70/100

Pharmacy pays

$0.17 /mL

~$100.18 /30

Type

Active ingredient

NORTRIPTYLINE HYDROCHLORIDE

IMIPRAMINE PAMOATE

Manufacturer

Specgx LLC

Dosage forms

Capsule

Drug class

Tricyclic Antidepressant

Boxed warning

None

Treats

Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

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Frequently asked questions

Which is better-rated, Pamelor or Tofranil-Pm?

Pamelor and Tofranil-Pm are tied at 3.5 out of 5 by our independent rating.

What is the difference between Pamelor and Tofranil-Pm?

Pamelor contains Nortriptyline Hydrochloride, while Tofranil-Pm contains Imipramine Pamoate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.