PALONOSETRON HYDROCHLORIDE vs ZOFRAN ODT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. PALONOSETRON HYDROCHLORIDE and ZOFRAN ODT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PALONOSETRON HYDROCHLORIDE	ZOFRAN ODT
Rating	70/100	68/100
Pharmacy pays	—	$0.15 /mL
Type	RX	RX
Active ingredient	PALONOSETRON HYDROCHLORIDE	ONDANSETRON
Manufacturer	Mylan Institutional	Sandoz
Dosage forms	Injectable, Solution	Tablet, orally disintegrating
Drug class	Serotonin-3 Receptor Antagonist	Serotonin-3 Receptor Antagonist
Boxed warning	None	None
Half-life	—	about 3 to 5 hours (roughly 4 hours) in healthy adults
Treats	—	Alcoholism

palonosetron hydrochloride zofran odt

Rating

70/100

68/100

Pharmacy pays

—

$0.15 /mL

Type

Active ingredient

PALONOSETRON HYDROCHLORIDE

ONDANSETRON

Manufacturer

Mylan Institutional

Sandoz

Dosage forms

Injectable, Solution

Tablet, orally disintegrating

Drug class

Serotonin-3 Receptor Antagonist

Boxed warning

None

Half-life

—

about 3 to 5 hours (roughly 4 hours) in healthy adults

Treats

—

Alcoholism

Frequently asked questions

Which is better-rated, Palonosetron Hydrochloride or Zofran ODT?

By our independent rating, Palonosetron Hydrochloride scores higher — 3.5 vs 3.4 out of 5 for Zofran ODT. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Palonosetron Hydrochloride and Zofran ODT?

Palonosetron Hydrochloride contains Palonosetron Hydrochloride, while Zofran ODT contains Ondansetron — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.