OXYCODONE HYDROCHLORIDE vs TRAMADOL HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. OXYCODONE HYDROCHLORIDE and TRAMADOL HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OXYCODONE HYDROCHLORIDE	TRAMADOL HYDROCHLORIDE
Rating	70/100	New
Pharmacy pays	$0.08 /mL	~$0.72 /30
Type	RX	RX
Active ingredient	OXYCODONE HYDROCHLORIDE	TRAMADOL HYDROCHLORIDE
Manufacturer	Vistapharm LLC	Cspc Ouyi
Dosage forms	Solution, Tablet, Tablet, extended release	Tablet, Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 3.5 to 4 hours	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)
Treats	Postoperative Pain	Pain

oxycodone hydrochloride tramadol hydrochloride

Rating

70/100

New

Pharmacy pays

$0.08 /mL

~$0.72 /30

Type

Active ingredient

OXYCODONE HYDROCHLORIDE

TRAMADOL HYDROCHLORIDE

Manufacturer

Vistapharm LLC

Cspc Ouyi

Dosage forms

Solution, Tablet, Tablet, extended release

Tablet, Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 3.5 to 4 hours

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Postoperative Pain

Pain

Frequently asked questions

What is the difference between Oxycodone Hydrochloride and Tramadol Hydrochloride?

Oxycodone Hydrochloride contains Oxycodone Hydrochloride, while Tramadol Hydrochloride contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.