OXAYDO vs ULTRAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. OXAYDO and ULTRAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OXAYDO	ULTRAM
Rating	New	70/100
Pharmacy pays	$0.08 /mL	~$0.72 /30
Type	RX	RX
Active ingredient	OXYCODONE HYDROCHLORIDE	TRAMADOL HYDROCHLORIDE
Manufacturer	Zyla	Janssen Pharms
Dosage forms	Tablet	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 3.5 to 4 hours	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)
Treats	Postoperative Pain	Pain

oxaydo ultram

Rating

New

70/100

Pharmacy pays

$0.08 /mL

~$0.72 /30

Type

Active ingredient

OXYCODONE HYDROCHLORIDE

TRAMADOL HYDROCHLORIDE

Manufacturer

Zyla

Janssen Pharms

Dosage forms

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 3.5 to 4 hours

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Postoperative Pain

Pain

Frequently asked questions

What is the difference between Oxaydo and Ultram?

Oxaydo contains Oxycodone Hydrochloride, while Ultram contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.