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OXAYDO vs SUBLIMAZE PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. OXAYDO and SUBLIMAZE PRESERVATIVE FREE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
72/100

Pharmacy pays

$0.08 /mL
$9.51 /mL

Type

RX
RX

Active ingredient

OXYCODONE HYDROCHLORIDE
FENTANYL CITRATE

Manufacturer

Dosage forms

Tablet
Injectable

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Half-life

about 3.5 to 4 hours

Treats

Postoperative Pain
Pain

Frequently asked questions

Which is cheaper, Oxaydo or Sublimaze Preservative Free?

Oxaydo costs pharmacies less to acquire — about $0.08 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Oxaydo and Sublimaze Preservative Free?

Oxaydo contains Oxycodone Hydrochloride, while Sublimaze Preservative Free contains Fentanyl Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.