OTREXUP vs PEMETREXED DISODIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. OTREXUP and PEMETREXED DISODIUM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OTREXUP	PEMETREXED DISODIUM
Rating	New	70/100
Pharmacy pays	~$4.92 /30	—
Type	RX	RX
Active ingredient	METHOTREXATE	PEMETREXED DISODIUM
Manufacturer	Assertio Speclty	Amneal
Dosage forms	Injectable	Injectable
Drug class	Folate Analog Metabolic Inhibitor	Folate Analog Metabolic Inhibitor
Boxed warning	Boxed warning	None
Half-life	about 3 to 10 hours	—
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms	Non-Small-Cell Lung Carcinoma, Mesothelial Neoplasms

otrexup pemetrexed disodium

Rating

New

70/100

Pharmacy pays

~$4.92 /30

—

Type

Active ingredient

METHOTREXATE

PEMETREXED DISODIUM

Manufacturer

Assertio Speclty

Amneal

Dosage forms

Injectable

Drug class

Folate Analog Metabolic Inhibitor

Boxed warning

None

Half-life

about 3 to 10 hours

—

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms

Non-Small-Cell Lung Carcinoma, Mesothelial Neoplasms

Frequently asked questions

What is the difference between Otrexup and Pemetrexed Disodium?

Otrexup contains Methotrexate, while Pemetrexed Disodium contains Pemetrexed Disodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.