OTEZLA vs OTEZLA XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	OTEZLA	OTEZLA XR
Rating	72/100	72/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	APREMILAST	APREMILAST
Manufacturer	Amgen Inc	Amgen Inc
Dosage forms	Tablet, Kit	Tablet, extended release
Drug class	Phosphodiesterase 4 Inhibitor	Phosphodiesterase 4 Inhibitor
Boxed warning	None	None
Half-life	about 6 to 9 hours (terminal elimination half-life)	about 6 to 9 hours (terminal elimination half-life)
Treats	Psoriatic Arthritis	Psoriatic Arthritis

otezla otezla xr

Rating

72/100

Pharmacy pays

—

Type

Active ingredient

APREMILAST

Manufacturer

Amgen Inc

Dosage forms

Tablet, Kit

Tablet, extended release

Drug class

Phosphodiesterase 4 Inhibitor

Boxed warning

None

Half-life

about 6 to 9 hours (terminal elimination half-life)

Treats

Psoriatic Arthritis

Frequently asked questions

Which is better-rated, Otezla or Otezla XR?

Otezla and Otezla XR are tied at 3.6 out of 5 by our independent rating.

What is the difference between Otezla and Otezla XR?

Both Otezla and Otezla XR share the active ingredient Apremilast.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.