OTEZLA XR vs ROFLUMILAST

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. OTEZLA XR and ROFLUMILAST are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OTEZLA XR	ROFLUMILAST
Rating	72/100	66/100
Pharmacy pays	—	~$10.09 /30
Type	RX	RX
Active ingredient	APREMILAST	ROFLUMILAST
Manufacturer	Amgen Inc	Torrent
Dosage forms	Tablet, extended release	Tablet
Drug class	Phosphodiesterase 4 Inhibitor	Phosphodiesterase 4 Inhibitor
Boxed warning	None	None
Half-life	about 6 to 9 hours (terminal elimination half-life)	—
Treats	Psoriatic Arthritis	Chronic Obstructive Pulmonary Disease

otezla xr roflumilast

Rating

72/100

66/100

Pharmacy pays

—

~$10.09 /30

Type

Active ingredient

APREMILAST

ROFLUMILAST

Manufacturer

Amgen Inc

Torrent

Dosage forms

Tablet, extended release

Tablet

Drug class

Phosphodiesterase 4 Inhibitor

Boxed warning

None

Half-life

about 6 to 9 hours (terminal elimination half-life)

—

Treats

Psoriatic Arthritis

Chronic Obstructive Pulmonary Disease

Frequently asked questions

Which is better-rated, Otezla XR or Roflumilast?

By our independent rating, Otezla XR scores higher — 3.6 vs 3.3 out of 5 for Roflumilast. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Otezla XR and Roflumilast?

Otezla XR contains Apremilast, while Roflumilast contains Roflumilast — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.