OSMOLEX ER vs SYMMETREL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	OSMOLEX ER	SYMMETREL
Rating	New	72/100
Pharmacy pays	~$4.67 /30	~$4.67 /30
Type	RX	RX
Active ingredient	AMANTADINE HYDROCHLORIDE	AMANTADINE HYDROCHLORIDE
Manufacturer	Supernus Pharms	Endo Pharms
Dosage forms	Tablet, extended release	Syrup, Tablet, Capsule
Drug class	Influenza A M2 Protein Inhibitor	Influenza A M2 Protein Inhibitor
Boxed warning	None	None
Half-life	about 17 hours (range roughly 10 to 25 hours); across studies it has averaged about 16 hours (range 9 to 31 hours) in healthy adults	about 17 hours (range roughly 10 to 25 hours); across studies it has averaged about 16 hours (range 9 to 31 hours) in healthy adults
Treats	Drug-Induced Dyskinesia, Dystonia, Human Influenza	Drug-Induced Dyskinesia, Dystonia, Human Influenza

osmolex er symmetrel

Rating

New

72/100

Pharmacy pays

~$4.67 /30

Type

Active ingredient

AMANTADINE HYDROCHLORIDE

Manufacturer

Supernus Pharms

Endo Pharms

Dosage forms

Tablet, extended release

Syrup, Tablet, Capsule

Drug class

Influenza A M2 Protein Inhibitor

Boxed warning

None

Half-life

about 17 hours (range roughly 10 to 25 hours); across studies it has averaged about 16 hours (range 9 to 31 hours) in healthy adults

Treats

Drug-Induced Dyskinesia, Dystonia, Human Influenza

Get symmetrelhigher-rated option

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Frequently asked questions

Which is cheaper, Osmolex ER or Symmetrel?

Pharmacies pay about the same to acquire either one — roughly $4.67 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Osmolex ER and Symmetrel?

Both Osmolex ER and Symmetrel share the active ingredient Amantadine Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.