ORTHO CYCLEN-21 vs ORTHO TRI-CYCLEN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Attribute	ORTHO CYCLEN-21	ORTHO TRI-CYCLEN
Rating	70/100	70/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	ETHINYL ESTRADIOL AND NORGESTIMATE	ETHINYL ESTRADIOL AND NORGESTIMATE
Manufacturer	Janssen Pharms	Janssen Pharms
Dosage forms	Tablet	Tablet
Drug class	—	—
Boxed warning	None	None

ortho cyclen-21 ortho tri-cyclen

Rating

70/100

Pharmacy pays

—

Type

Active ingredient

ETHINYL ESTRADIOL AND NORGESTIMATE

Manufacturer

Janssen Pharms

Dosage forms

Tablet

Drug class

—

Boxed warning

None

Frequently asked questions

Which is better-rated, Ortho Cyclen-21 or Ortho Tri-Cyclen?

Ortho Cyclen-21 and Ortho Tri-Cyclen are tied at 3.5 out of 5 by our independent rating.

What is the difference between Ortho Cyclen-21 and Ortho Tri-Cyclen?

Both Ortho Cyclen-21 and Ortho Tri-Cyclen share the active ingredient Ethinyl Estradiol and Norgestimate.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.