OPDIVO vs PROLEUKIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. OPDIVO and PROLEUKIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OPDIVO	PROLEUKIN
Rating	72/100	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	NIVOLUMAB	ALDESLEUKIN
Manufacturer	Bristol Myers Squibb	Chiron
Dosage forms	Injectable	Injectable
Drug class	Programmed Death Receptor-1 Blocking Antibody	Lymphocyte Growth Factor
Boxed warning	None	Boxed warning
Treats	Urinary Bladder Neoplasms, Non-Small-Cell Lung Carcinoma, Squamous Cell Carcinoma	Renal Cell Carcinoma, Non-Hodgkin Lymphoma, Melanoma

opdivo proleukin

Rating

72/100

New

Pharmacy pays

—

Type

Active ingredient

NIVOLUMAB

ALDESLEUKIN

Manufacturer

Bristol Myers Squibb

Chiron

Dosage forms

Injectable

Drug class

Programmed Death Receptor-1 Blocking Antibody

Lymphocyte Growth Factor

Boxed warning

None

Boxed warning

Treats

Urinary Bladder Neoplasms, Non-Small-Cell Lung Carcinoma, Squamous Cell Carcinoma

Renal Cell Carcinoma, Non-Hodgkin Lymphoma, Melanoma

Frequently asked questions

What is the difference between Opdivo and Proleukin?

Opdivo contains Nivolumab, while Proleukin contains Aldesleukin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.