OPANA vs WESTADONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. OPANA and WESTADONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OPANA	WESTADONE
Rating	72/100	68/100
Pharmacy pays	~$36.74 /30	$0.18 /mL
Type	RX	RX
Active ingredient	OXYMORPHONE HYDROCHLORIDE	METHADONE HYDROCHLORIDE
Manufacturer	Endo Pharms	Sandoz
Dosage forms	Tablet, Injectable	Tablet, effervescent
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 8 to 59 hours (terminal/elimination half-life; a very wide range)
Treats	Pain	Opioid-Related Disorders, Intractable Pain

opana westadone

Rating

72/100

68/100

Pharmacy pays

~$36.74 /30

$0.18 /mL

Type

Active ingredient

OXYMORPHONE HYDROCHLORIDE

METHADONE HYDROCHLORIDE

Manufacturer

Endo Pharms

Sandoz

Dosage forms

Tablet, Injectable

Tablet, effervescent

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

Treats

Pain

Opioid-Related Disorders, Intractable Pain

Frequently asked questions

Which is better-rated, Opana or Westadone?

By our independent rating, Opana scores higher — 3.6 vs 3.4 out of 5 for Westadone. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Opana and Westadone?

Opana contains Oxymorphone Hydrochloride, while Westadone contains Methadone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.