OPANA vs VANTRELA ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. OPANA and VANTRELA ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OPANA	VANTRELA ER
Rating	72/100	New
Pharmacy pays	~$36.74 /30	~$239.83 /30
Type	RX	RX
Active ingredient	OXYMORPHONE HYDROCHLORIDE	HYDROCODONE BITARTRATE
Manufacturer	Endo Pharms	Teva Branded Pharm
Dosage forms	Tablet, Injectable	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 3.8 hours (3.8 ± 0.3 hours)
Treats	Pain	Cough, Obstructive Lung Diseases, Postoperative Pain

opana vantrela er

Rating

72/100

New

Pharmacy pays

~$36.74 /30

~$239.83 /30

Type

Active ingredient

OXYMORPHONE HYDROCHLORIDE

HYDROCODONE BITARTRATE

Manufacturer

Endo Pharms

Teva Branded Pharm

Dosage forms

Tablet, Injectable

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 3.8 hours (3.8 ± 0.3 hours)

Treats

Pain

Cough, Obstructive Lung Diseases, Postoperative Pain

Frequently asked questions

Which is cheaper, Opana or Vantrela ER?

Opana costs pharmacies less to acquire — about $36.74 vs $239.83 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Opana and Vantrela ER?

Opana contains Oxymorphone Hydrochloride, while Vantrela ER contains Hydrocodone Bitartrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.