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OPANA vs TRAMADOL HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. OPANA and TRAMADOL HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

opanatramadol hydrochloride

Rating

72/100
New

Pharmacy pays

~$36.74 /30
~$0.72 /30

Type

RX
RX

Active ingredient

OXYMORPHONE HYDROCHLORIDE
TRAMADOL HYDROCHLORIDE

Manufacturer

Endo Pharms
Cspc Ouyi

Dosage forms

Tablet, Injectable
Tablet, Tablet, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
Boxed warning

Half-life

—
about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Pain
Pain

Frequently asked questions

Which is cheaper, Opana or Tramadol Hydrochloride?

Tramadol Hydrochloride costs pharmacies less to acquire — about $0.72 vs $36.74 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Opana and Tramadol Hydrochloride?

Opana contains Oxymorphone Hydrochloride, while Tramadol Hydrochloride contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.