OPANA vs OXAYDO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. OPANA and OXAYDO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OPANA	OXAYDO
Rating	72/100	New
Pharmacy pays	~$36.74 /30	$0.08 /mL
Type	RX	RX
Active ingredient	OXYMORPHONE HYDROCHLORIDE	OXYCODONE HYDROCHLORIDE
Manufacturer	Endo Pharms	Zyla
Dosage forms	Tablet, Injectable	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	—	about 3.5 to 4 hours
Treats	Pain	Postoperative Pain

opana oxaydo

Rating

72/100

New

Pharmacy pays

~$36.74 /30

$0.08 /mL

Type

Active ingredient

OXYMORPHONE HYDROCHLORIDE

OXYCODONE HYDROCHLORIDE

Manufacturer

Endo Pharms

Zyla

Dosage forms

Tablet, Injectable

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

—

about 3.5 to 4 hours

Treats

Pain

Postoperative Pain

Frequently asked questions

What is the difference between Opana and Oxaydo?

Opana contains Oxymorphone Hydrochloride, while Oxaydo contains Oxycodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.