OPANA vs ORAMORPH SR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Possible drug interaction. OPANA and ORAMORPH SR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OPANA	ORAMORPH SR
Rating	72/100	New
Pharmacy pays	~$36.74 /30	$2.61 /mL
Type	RX	RX
Active ingredient	OXYMORPHONE HYDROCHLORIDE	MORPHINE SULFATE
Manufacturer	Endo Pharms	Xanodyne Pharm
Dosage forms	Tablet, Injectable	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 2 hours
Treats	Pain	Dyspnea, Intractable Pain

opana oramorph sr

Rating

72/100

New

Pharmacy pays

~$36.74 /30

$2.61 /mL

Type

Active ingredient

OXYMORPHONE HYDROCHLORIDE

MORPHINE SULFATE

Manufacturer

Endo Pharms

Xanodyne Pharm

Dosage forms

Tablet, Injectable

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 2 hours

Treats

Pain

Dyspnea, Intractable Pain

Frequently asked questions

What is the difference between Opana and Oramorph SR?

Opana contains Oxymorphone Hydrochloride, while Oramorph SR contains Morphine Sulfate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.