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ONZETRA XSAIL vs ZECUITY

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Rating

New
New

Pharmacy pays

~$481.89 /30
~$481.89 /30

Type

RX
RX

Active ingredient

SUMATRIPTAN SUCCINATE
SUMATRIPTAN SUCCINATE

Dosage forms

Capsule
System

Drug class

Serotonin-1b and Serotonin-1d Receptor Agonist
Serotonin-1b and Serotonin-1d Receptor Agonist

Boxed warning

None
None

Half-life

about 2 hours (terminal elimination half-life 115 ± 19 minutes)
about 2 hours (terminal elimination half-life 115 ± 19 minutes)

Treats

Cluster Headache, Migraine Disorders
Cluster Headache, Migraine Disorders

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Frequently asked questions

Which is cheaper, Onzetra Xsail or Zecuity?

Pharmacies pay about the same to acquire either one — roughly $481.89 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Onzetra Xsail and Zecuity?

Both Onzetra Xsail and Zecuity share the active ingredient Sumatriptan Succinate.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.