ONTRALFY vs PRECEDEX

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. ONTRALFY and PRECEDEX are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ONTRALFY	PRECEDEX
Rating	New	60/100
Pharmacy pays	~$1.00 /30	—
Type	RX	RX
Active ingredient	TIZANIDINE HYDROCHLORIDE	DEXMEDETOMIDINE HYDROCHLORIDE
Manufacturer	Fidelity Biopharma	Hospira
Dosage forms	Solution	Injectable
Drug class	Central Alpha-2 Adrenergic Agonist	Central Alpha-2 Adrenergic Agonist
Boxed warning	None	None
Half-life	about 2.5 hours	—
Treats	Muscle Cramp, Muscle Rigidity, Muscle Spasticity	Pain, Psychomotor Agitation

ontralfy precedex

Rating

New

60/100

Pharmacy pays

~$1.00 /30

—

Type

Active ingredient

TIZANIDINE HYDROCHLORIDE

DEXMEDETOMIDINE HYDROCHLORIDE

Manufacturer

Fidelity Biopharma

Hospira

Dosage forms

Solution

Injectable

Drug class

Central Alpha-2 Adrenergic Agonist

Boxed warning

None

Half-life

about 2.5 hours

—

Treats

Muscle Cramp, Muscle Rigidity, Muscle Spasticity

Pain, Psychomotor Agitation

Frequently asked questions

What is the difference between Ontralfy and Precedex?

Ontralfy contains Tizanidine Hydrochloride, while Precedex contains Dexmedetomidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.