ONTRALFY vs ONYDA XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. ONTRALFY and ONYDA XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ONTRALFY	ONYDA XR
Rating	New	72/100
Pharmacy pays	~$1.00 /30	~$1.05 /30
Type	RX	RX
Active ingredient	TIZANIDINE HYDROCHLORIDE	CLONIDINE HYDROCHLORIDE
Manufacturer	Fidelity Biopharma	Tris Pharma Inc
Dosage forms	Solution	Suspension, extended release
Drug class	Central Alpha-2 Adrenergic Agonist	Central Alpha-2 Adrenergic Agonist
Boxed warning	None	None
Half-life	about 2.5 hours	about 12 to 16 hours
Treats	Muscle Cramp, Muscle Rigidity, Muscle Spasticity	Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea

ontralfy onyda xr

Rating

New

72/100

Pharmacy pays

~$1.00 /30

~$1.05 /30

Type

Active ingredient

TIZANIDINE HYDROCHLORIDE

CLONIDINE HYDROCHLORIDE

Manufacturer

Fidelity Biopharma

Tris Pharma Inc

Dosage forms

Solution

Suspension, extended release

Drug class

Central Alpha-2 Adrenergic Agonist

Boxed warning

None

Half-life

about 2.5 hours

about 12 to 16 hours

Treats

Muscle Cramp, Muscle Rigidity, Muscle Spasticity

Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea

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Frequently asked questions

Which is cheaper, Ontralfy or Onyda XR?

Ontralfy costs pharmacies less to acquire — about $1.00 vs $1.05 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Ontralfy and Onyda XR?

Ontralfy contains Tizanidine Hydrochloride, while Onyda XR contains Clonidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.