ONDANSETRON vs ZOFRAN PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Possible drug interaction. ONDANSETRON and ZOFRAN PRESERVATIVE FREE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ONDANSETRON	ZOFRAN PRESERVATIVE FREE
Rating	56/100	68/100
Pharmacy pays	$0.15 /mL	$0.15 /mL
Type	RX	RX
Active ingredient	ONDANSETRON	ONDANSETRON HYDROCHLORIDE
Manufacturer	Teva	Sandoz
Dosage forms	Injectable, Solution, Tablet, Tablet, orally disintegrating	Injectable
Drug class	Serotonin-3 Receptor Antagonist	Serotonin-3 Receptor Antagonist
Boxed warning	None	None
Half-life	about 3 to 5 hours (roughly 4 hours) in healthy adults	about 3 to 5 hours (roughly 4 hours) in healthy adults
Treats	Alcoholism	Alcoholism

ondansetron zofran preservative free

Rating

56/100

68/100

Pharmacy pays

$0.15 /mL

Type

Active ingredient

ONDANSETRON

ONDANSETRON HYDROCHLORIDE

Manufacturer

Teva

Sandoz

Dosage forms

Injectable, Solution, Tablet, Tablet, orally disintegrating

Injectable

Drug class

Serotonin-3 Receptor Antagonist

Boxed warning

None

Half-life

about 3 to 5 hours (roughly 4 hours) in healthy adults

Treats

Alcoholism

Frequently asked questions

Which is better-rated, Ondansetron or Zofran Preservative Free?

By our independent rating, Zofran Preservative Free scores higher — 3.4 vs 2.8 out of 5 for Ondansetron. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Ondansetron or Zofran Preservative Free?

Pharmacies pay about the same to acquire either one — roughly $0.15 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Ondansetron and Zofran Preservative Free?

Ondansetron contains Ondansetron, while Zofran Preservative Free contains Ondansetron Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.