ONDANSETRON vs ZOFRAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. ONDANSETRON and ZOFRAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ONDANSETRON	ZOFRAN
Rating	56/100	68/100
Pharmacy pays	$0.15 /mL	$0.15 /mL
Type	RX	RX
Active ingredient	ONDANSETRON	ONDANSETRON HYDROCHLORIDE
Manufacturer	Teva	Sandoz
Dosage forms	Injectable, Solution, Tablet, Tablet, orally disintegrating	Tablet
Drug class	Serotonin-3 Receptor Antagonist	Serotonin-3 Receptor Antagonist
Boxed warning	None	None
Half-life	about 3 to 5 hours (roughly 4 hours) in healthy adults	about 3 to 5 hours (roughly 4 hours) in healthy adults
Treats	Alcoholism	Alcoholism

ondansetron zofran

Rating

56/100

68/100

Pharmacy pays

$0.15 /mL

Type

Active ingredient

ONDANSETRON

ONDANSETRON HYDROCHLORIDE

Manufacturer

Teva

Sandoz

Dosage forms

Injectable, Solution, Tablet, Tablet, orally disintegrating

Tablet

Drug class

Serotonin-3 Receptor Antagonist

Boxed warning

None

Half-life

about 3 to 5 hours (roughly 4 hours) in healthy adults

Treats

Alcoholism

Frequently asked questions

Which is better-rated, Ondansetron or Zofran?

By our independent rating, Zofran scores higher — 3.4 vs 2.8 out of 5 for Ondansetron. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Ondansetron or Zofran?

Pharmacies pay about the same to acquire either one — roughly $0.15 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Ondansetron and Zofran?

Ondansetron contains Ondansetron, while Zofran contains Ondansetron Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.