ONDANSETRON vs POSFREA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. ONDANSETRON and POSFREA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ONDANSETRON	POSFREA
Rating	56/100	New
Pharmacy pays	$0.15 /mL	—
Type	RX	RX
Active ingredient	ONDANSETRON	PALONOSETRON HYDROCHLORIDE
Manufacturer	Teva	Avyxa Holdings
Dosage forms	Injectable, Solution, Tablet, Tablet, orally disintegrating	Injectable
Drug class	Serotonin-3 Receptor Antagonist	Serotonin-3 Receptor Antagonist
Boxed warning	None	None
Half-life	about 3 to 5 hours (roughly 4 hours) in healthy adults	—
Treats	Alcoholism	—

ondansetron posfrea

Rating

56/100

New

Pharmacy pays

$0.15 /mL

—

Type

Active ingredient

ONDANSETRON

PALONOSETRON HYDROCHLORIDE

Manufacturer

Teva

Avyxa Holdings

Dosage forms

Injectable, Solution, Tablet, Tablet, orally disintegrating

Injectable

Drug class

Serotonin-3 Receptor Antagonist

Boxed warning

None

Half-life

about 3 to 5 hours (roughly 4 hours) in healthy adults

—

Treats

Alcoholism

—

Frequently asked questions

What is the difference between Ondansetron and Posfrea?

Ondansetron contains Ondansetron, while Posfrea contains Palonosetron Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.