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ONDANSETRON HYDROCHLORIDE vs ZOFRAN PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Rating

70/100
68/100

Pharmacy pays

$0.15 /mL
$0.15 /mL

Type

RX
RX

Active ingredient

ONDANSETRON HYDROCHLORIDE
ONDANSETRON HYDROCHLORIDE

Dosage forms

Solution
Injectable

Drug class

Serotonin-3 Receptor Antagonist
Serotonin-3 Receptor Antagonist

Boxed warning

None
None

Half-life

about 3 to 5 hours (roughly 4 hours) in healthy adults
about 3 to 5 hours (roughly 4 hours) in healthy adults

Treats

Alcoholism
Alcoholism

Frequently asked questions

Which is better-rated, Ondansetron Hydrochloride or Zofran Preservative Free?

By our independent rating, Ondansetron Hydrochloride scores higher — 3.5 vs 3.4 out of 5 for Zofran Preservative Free. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Ondansetron Hydrochloride or Zofran Preservative Free?

Pharmacies pay about the same to acquire either one — roughly $0.15 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Ondansetron Hydrochloride and Zofran Preservative Free?

Both Ondansetron Hydrochloride and Zofran Preservative Free share the active ingredient Ondansetron Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.