ONDANSETRON HYDROCHLORIDE vs ZOFRAN ODT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. ONDANSETRON HYDROCHLORIDE and ZOFRAN ODT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ONDANSETRON HYDROCHLORIDE	ZOFRAN ODT
Rating	70/100	68/100
Pharmacy pays	$0.15 /mL	$0.15 /mL
Type	RX	RX
Active ingredient	ONDANSETRON HYDROCHLORIDE	ONDANSETRON
Manufacturer	Lannett Co Inc	Sandoz
Dosage forms	Solution	Tablet, orally disintegrating
Drug class	Serotonin-3 Receptor Antagonist	Serotonin-3 Receptor Antagonist
Boxed warning	None	None
Half-life	about 3 to 5 hours (roughly 4 hours) in healthy adults	about 3 to 5 hours (roughly 4 hours) in healthy adults
Treats	Alcoholism	Alcoholism

ondansetron hydrochloride zofran odt

Rating

70/100

68/100

Pharmacy pays

$0.15 /mL

Type

Active ingredient

ONDANSETRON HYDROCHLORIDE

ONDANSETRON

Manufacturer

Lannett Co Inc

Sandoz

Dosage forms

Solution

Tablet, orally disintegrating

Drug class

Serotonin-3 Receptor Antagonist

Boxed warning

None

Half-life

about 3 to 5 hours (roughly 4 hours) in healthy adults

Treats

Alcoholism

Frequently asked questions

Which is better-rated, Ondansetron Hydrochloride or Zofran ODT?

By our independent rating, Ondansetron Hydrochloride scores higher — 3.5 vs 3.4 out of 5 for Zofran ODT. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Ondansetron Hydrochloride or Zofran ODT?

Pharmacies pay about the same to acquire either one — roughly $0.15 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Ondansetron Hydrochloride and Zofran ODT?

Ondansetron Hydrochloride contains Ondansetron Hydrochloride, while Zofran ODT contains Ondansetron — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.