OMEPRAZOLE vs PRILOSEC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Attribute	OMEPRAZOLE	PRILOSEC
Rating	New	70/100
Pharmacy pays	~$1.52 /30	~$1.52 /30
Type	RX	RX
Active ingredient	OMEPRAZOLE	OMEPRAZOLE
Manufacturer	Hetero Labs Ltd III	Astrazeneca
Dosage forms	Capsule, Capsule, delayed release, Oral pellets, Tablet, delayed release, Tablet, orally disintegrating, delayed release	Powder, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

omeprazole prilosec

Rating

New

70/100

Pharmacy pays

~$1.52 /30

Type

Active ingredient

OMEPRAZOLE

Manufacturer

Hetero Labs Ltd III

Astrazeneca

Dosage forms

Capsule, Capsule, delayed release, Oral pellets, Tablet, delayed release, Tablet, orally disintegrating, delayed release

Powder, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is cheaper, Omeprazole or Prilosec?

Pharmacies pay about the same to acquire either one — roughly $1.52 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Omeprazole and Prilosec?

Both Omeprazole and Prilosec share the active ingredient Omeprazole.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.