OMEPRAZOLE vs PANTOPRAZOLE SODIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. OMEPRAZOLE and PANTOPRAZOLE SODIUM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OMEPRAZOLE	PANTOPRAZOLE SODIUM
Rating	New	New
Pharmacy pays	~$1.52 /30	~$120.76 /30
Type	RX	RX
Active ingredient	OMEPRAZOLE	PANTOPRAZOLE SODIUM
Manufacturer	Hetero Labs Ltd III	Annora Pharma
Dosage forms	Capsule, Capsule, delayed release, Oral pellets, Tablet, delayed release, Tablet, orally disintegrating, delayed release	Powder, delayed release, Injectable, Solution, Powder, Tablet, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults	about 1 hour
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Esophagitis, Gastroesophageal Reflux, Heartburn

omeprazole pantoprazole sodium

Rating

New

Pharmacy pays

~$1.52 /30

~$120.76 /30

Type

Active ingredient

OMEPRAZOLE

PANTOPRAZOLE SODIUM

Manufacturer

Hetero Labs Ltd III

Annora Pharma

Dosage forms

Capsule, Capsule, delayed release, Oral pellets, Tablet, delayed release, Tablet, orally disintegrating, delayed release

Powder, delayed release, Injectable, Solution, Powder, Tablet, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

about 1 hour

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

Esophagitis, Gastroesophageal Reflux, Heartburn

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Frequently asked questions

Which is cheaper, Omeprazole or Pantoprazole Sodium?

Omeprazole costs pharmacies less to acquire — about $1.52 vs $120.76 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Omeprazole and Pantoprazole Sodium?

Omeprazole contains Omeprazole, while Pantoprazole Sodium contains Pantoprazole Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.