OMEPRAZOLE MAGNESIUM vs PRILOSEC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 11, 2026·How we rate

Possible drug interaction. OMEPRAZOLE MAGNESIUM and PRILOSEC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OMEPRAZOLE MAGNESIUM	PRILOSEC
Rating	68/100	70/100
Pharmacy pays	—	~$1.52 /30
Type	RX	RX
Active ingredient	OMEPRAZOLE MAGNESIUM	OMEPRAZOLE
Manufacturer	Aurobindo Pharma Ltd	Astrazeneca
Dosage forms	Capsule, delayed release	Powder, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

omeprazole magnesium prilosec

Rating

68/100

70/100

Pharmacy pays

—

~$1.52 /30

Type

Active ingredient

OMEPRAZOLE MAGNESIUM

OMEPRAZOLE

Manufacturer

Aurobindo Pharma Ltd

Astrazeneca

Dosage forms

Capsule, delayed release

Powder, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is better-rated, Omeprazole Magnesium or Prilosec?

By our independent rating, Prilosec scores higher — 3.5 vs 3.4 out of 5 for Omeprazole Magnesium. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Omeprazole Magnesium and Prilosec?

Omeprazole Magnesium contains Omeprazole Magnesium, while Prilosec contains Omeprazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.