NUCYNTA vs TAPENTADOL HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Attribute	NUCYNTA	TAPENTADOL HYDROCHLORIDE
Rating	New	New
Pharmacy pays	~$335.93 /30	~$335.93 /30
Type	RX	RX
Active ingredient	TAPENTADOL HYDROCHLORIDE	TAPENTADOL HYDROCHLORIDE
Manufacturer	Collegium Pharm Inc	Humanwell
Dosage forms	Tablet	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 5 hours (terminal half-life, on average, after oral administration)	about 5 hours (terminal half-life, on average, after oral administration)
Treats	Pain	Pain

nucynta tapentadol hydrochloride

Rating

New

Pharmacy pays

~$335.93 /30

Type

Active ingredient

TAPENTADOL HYDROCHLORIDE

Manufacturer

Collegium Pharm Inc

Humanwell

Dosage forms

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 5 hours (terminal half-life, on average, after oral administration)

Treats

Pain

Frequently asked questions

Which is cheaper, Nucynta or Tapentadol Hydrochloride?

Pharmacies pay about the same to acquire either one — roughly $335.93 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Nucynta and Tapentadol Hydrochloride?

Both Nucynta and Tapentadol Hydrochloride share the active ingredient Tapentadol Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.