NUCYNTA vs OXYCODONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 14, 2026·How we rate

Possible drug interaction. NUCYNTA and OXYCODONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NUCYNTA	OXYCODONE HYDROCHLORIDE
Rating	New	70/100
Pharmacy pays	~$342.56 /30	$0.08 /mL
Type	RX	RX
Active ingredient	TAPENTADOL HYDROCHLORIDE	OXYCODONE HYDROCHLORIDE
Manufacturer	Collegium Pharm Inc	Vistapharm LLC
Dosage forms	Tablet	Solution, Tablet, Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	about 5 hours (terminal half-life, on average, after oral administration)	about 3.5 to 4 hours
Treats	Pain	Postoperative Pain

nucynta oxycodone hydrochloride

Rating

New

70/100

Pharmacy pays

~$342.56 /30

$0.08 /mL

Type

Active ingredient

TAPENTADOL HYDROCHLORIDE

OXYCODONE HYDROCHLORIDE

Manufacturer

Collegium Pharm Inc

Vistapharm LLC

Dosage forms

Tablet

Solution, Tablet, Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 5 hours (terminal half-life, on average, after oral administration)

about 3.5 to 4 hours

Treats

Pain

Postoperative Pain

Frequently asked questions

What is the difference between Nucynta and Oxycodone Hydrochloride?

Nucynta contains Tapentadol Hydrochloride, while Oxycodone Hydrochloride contains Oxycodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.