NUCYNTA vs NUMORPHAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 14, 2026·How we rate

Possible drug interaction. NUCYNTA and NUMORPHAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NUCYNTA	NUMORPHAN
Rating	New	72/100
Pharmacy pays	~$342.56 /30	~$36.74 /30
Type	RX	RX
Active ingredient	TAPENTADOL HYDROCHLORIDE	OXYMORPHONE HYDROCHLORIDE
Manufacturer	Collegium Pharm Inc	Endo Pharms
Dosage forms	Tablet	Suppository
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	about 5 hours (terminal half-life, on average, after oral administration)	—
Treats	Pain	Pain

nucynta numorphan

Rating

New

72/100

Pharmacy pays

~$342.56 /30

~$36.74 /30

Type

Active ingredient

TAPENTADOL HYDROCHLORIDE

OXYMORPHONE HYDROCHLORIDE

Manufacturer

Collegium Pharm Inc

Endo Pharms

Dosage forms

Tablet

Suppository

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 5 hours (terminal half-life, on average, after oral administration)

—

Treats

Pain

Frequently asked questions

Which is cheaper, Nucynta or Numorphan?

Numorphan costs pharmacies less to acquire — about $36.74 vs $342.56 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Nucynta and Numorphan?

Nucynta contains Tapentadol Hydrochloride, while Numorphan contains Oxymorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.